| Disease
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Findings
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| Primary peritonitis
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Spontaneous bacterial peritonitis
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- Absence of GI perforation, most closely associated with cirrhosis and advanced liver disease.
- Presents with abrupt onset of fever, abdominal pain, distension, and rebound tenderness.
- Most have clinical and biochemical manifestations of advanced cirrhosis or nephrosis like leukocytosis,hypoalbuminemia,
- a prolonged prothrombin time. SAAG >1.1 g/dL, ↑s.lactic acid level, or a ↓ascitic fluid pH (< 7.31) supports the diagnosis. Gram staining reveals bacteria in only 25% of cases.
- Diagnosed by analysis of the ascitic fluid which reveals WBC > 500/ML, and PMN >250cells/ml.
- Culture of ascitic fluid inoculated immediately into blood culture media at the bedside usually reveals a single enteric organism, most commonly Escherichia coli, Klebsiella, or streptococci.
- Once diagnosed,it is treated with Ceftriaxone.
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| Tuberculous peritonitis
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- Seen in 0.5% of new cases of tuberculosis particularly in young women in endemic areas as a primary infection.
- Presents with abdominal pain and distension, fever, night sweats, weight loss, and altered bowel habits.
- Ascites is present in about half of cases. Abdominal mass may be felt in a third of cases. The peritoneal fluid is characterized by a protein concentration > 3 g/dL with < 1.1 g/dL SAAG and lymphocyte predominance of WBC.
- Definitive diagnosis in 80% of cases is by culture. Most patients presenting acutely are diagnosed only by laparotomy.
- Combination antituberculosis chemotherapy is preferred in chronic cases.
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| Continuous Ambulatory Peritoneal Dialysis (CAPD peritonitis)
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- Peritonitis is one of the major complications of peritoneal dialysis & 72.6% occurred within the first six months of peritoneal dialysis.
- Historically, coagulase-negative staphylococci were the most common cause of peritonitis in CAPD, presumably due to touch contamination or infection via the pericatheter route.
- Majority of peritonitis cases are caused by bacteria(50%-due to gram positive organisms, 15% to gram negative organisms,20% were culture negative.2% of cases are caused by fungi, mostly Candida species. Polymicrobial infection in 4%.Exit-site infection was present in 13% and a peritoneal fluid leak in 3 % and M.tuberculosis 0.1%.
- Treatment for peritoneal dialysis-associated peritonitis consists of antimicrobial therapy, in some cases catheter removal is also warranted.
- Additional therapies for relapsing or recurrent peritonitis may include fibrinolytic agents and peritoneal lavage. Most episodes of peritoneal dialysis-associated peritonitis resolve with outpatient antibiotic treatment.
- Initial empiric antibiotic coverage for peritoneal dialysis-associated peritonitis consists of coverage for gram-positive organisms (by vancomycin or a first-generation cephalosporin) and gram-negative organisms (by a third-generation cephalosporin or an aminoglycoside). Subsequently, the regimen should be adjusted based on culture and sensitivity data. Cure rates are approximately 75%.
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| Secondary peritonitis
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Acute bacterial secondary peritonitis
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- Occurs after perforating, penetrating, inflammatory, infectious, or ischemic injuries of the GI or GU tracts. Most often follows disruption of a hollow viscus→chemical peritonitis→bacterial peritonitis(polymicrobial, includes aerobic gram negative {E coli, Klebsiella, Enterobacter, Proteus mirabilis} and gram positive { Enterococcus, Streptococcus} and anaerobes {Bacteroides, clostridia}).
- Presents with abdominal pain, tenderness, guarding or rigidity, distension, free peritoneal air, and diminished bowel sounds. Signs that reflect irritation of the parietal peritoneum resulting ileus. Systemic findings include fever, chills or rigors, tachycardia, sweating, tachypnea, restlessness, dehydration, oliguria, disorientation, and, ultimately, refractory shock.
- Peritoneal lavage, Laparoscopy are the treatment of choice.
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| Biliary peritonitis
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| Tertiary peritonitis
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| Familial Mediterranean fever (periodic peritonitis, familial paroxysmal polyserositis)
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| Granulomatous peritonitis
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| Sclerosing encapsulating peritonitis
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| Intraperitoneal abscesses
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- Most common etiologies being Gastrointestinal perforations, postoperative complications, and penetrating injuries.
- Signs and symptoms depend on the location of the abscess within the peritoneal cavity and the extent of involvement of the surrounding structures.
- Diagnosis is suspected in any patient with a predisposing condition. In a third of cases it occurs as a sequela of generalized peritonitis.
- The pathogenic organisms are similar to those responsible for peritonitis, but anaerobic organisms occupy an important role.
- Diagnosed best by CT scan of the abdomen.
- The mortality rate of serious intra-abdominal abscesses is about 30%.
- Treatment consists of prompt and complete CT or US guided drainage of the abscess, control of the primary cause, and adjunctive use of effective antibiotics. Open drainage is reserved for abscesses for which percutaneous drainage is inappropriate or unsuccessful.
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| Peritoneal mesothelioma
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- Arises from the mesothelium lining the peritoneal cavity.
- Its incidence is approximately 300-500 new cases being diagnosed in the United States each year. As with pleural mesothelioma, there is an association with an asbestos exposure.
- Most commonly affects men at the age of 50-69 years. Patients most often present with abdominal pain and later increased abdominal girth and ascites along with anorexia, weight loss and abdominal pain. CT with intravenous contrast typically demonstrates the thickening of the peritoneum. Laparoscopy with tissue biopsy or CT guided tissue biopsy with immunohistochemical staining for calretinin, cytokeratin 5/6, mesothelin, and Wilms tumor 1 antigen remain the gold standard for diagnosis. Mean time from diagnosis to death is less than 1 year without treatment. At laparotomy the goal is cytoreduction with excision. Debulking surgery and intraperitoneal chemotherapy improves survival in some cases.
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| peritoneal carcinomatosis
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Associated with a history of ovarian or GI tract malignancy.Symptoms include ascites, abdominal pain, nausea, vomiting.
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