Cytomegalovirus infection historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Kuchkuntla, M.B.B.S[2]
Overview
Historical Perspective
- In 1881, Ribbert described the presence of inclusion bodies in the cells in sections of kidney of a still born and he described them as cells similar to protozoan cells with eccentrically placed nuclei and a “central nuclear body” surrounded by clear halo.
- In 1921, Goodpasture and Talbert were the first to suggest that these cell inclusions could be due to a viral agent.
- By 1932, 25 cases of a congenial infection characterized by petechiae, hepatosplenomegaly, and intracerebral calcification with intranuclear inclusion bodies were described. Wyatt et al. [7] suggested the name, “generalized cytomegalic inclusion disease (CID).
- In 1950, Smith and Vellios reported that infection can occur in-utero.
- In 1956-57 Weller, Smith and Rowe independently isolated CMV virus and grew it in culture.
- In 1960, Weller from Harvard University, coined the term "cytomegalovirus" and isolated the virus from the urine sample of an infant with generalized disease.