Graft-versus-host disease physical examination
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Graft-versus-host disease |
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Differentiating Graft-versus-host disease from other Diseases |
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Graft-versus-host disease physical examination On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2]
Overview
The physical exam for GvHD focuses on the organ involved, including the skin, liver, and GI tract.
Physical Examination
- Skin: Exam findings include erythema, maculopapular rash, and hyperpigmentation.[1] Lichen planus-like lesions have been observed in skin GvHD.[1]
- Liver: Exam findings include jaundice, pruritis, scleral icterus, leg swelling, tenderness in the right upper quadrant of the abdomen, bleeding from coagulopathy. The classic physical exam findings are suggestive of cholestatic hepatitis.[1]
- GI tract: Exam findings include abdominal tenderness, diarrhea, hyperactive or hypoactive bowel sounds.
- Lungs: Exam findings include decreased breath sounds and crackles (if fluid fills the alveolar space).
References
- ↑ 1.0 1.1 1.2 Socié G, Ritz J (2014). "Current issues in chronic graft-versus-host disease". Blood. 124 (3): 374–84. doi:10.1182/blood-2014-01-514752. PMC 4102710. PMID 24914139.