Insulinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

• There is no established system for the classification of [disease name].

OR

• [Disease name] may be classified according to [classification method] into [number] subtypes/groups: [group1], [group2], [group3], and [group4].

OR

• [Disease name] may be classified into [large number > 6] subtypes based on [classification method 1], [classification method 2], and [classification method 3].
• [Disease name] may be classified into several subtypes based on [classification method 1], [classification method 2], and [classification method 3].

OR

• Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.

OR

• If the staging system involves specific and characteristic findings and features:
• According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].

OR

• The staging of [malignancy name] is based on the [staging system].

OR

• There is no established system for the staging of [malignancy name].

Classification

• Insulinoma may be classified according to malignant potential into 2 subtypes/groups:
  • Benign
  • Malignant
    
    • 90% of insulinoma are benign in nature while 10% has malignant potential to invade adjacent soft tissues or structures

• Previously insulinoma was classified into 2 subtypes based on hormanal level as determined by radioimmunoassay:
  • Group A of abundant B cells with trabecular arrangement and uniform insulin immunofluorescence
  • Group B of scarce cells with medullary arrangement and irregular immunofluorescence
• [Disease name] may be classified into several subtypes based on:
  • [classification method 1]
  • [classification method 2]
  • [classification method 3]

OR

• Based on the duration of symptoms, [disease name] may be classified as either acute or chronic.

OR

• If the staging system involves specific and characteristic findings and features:
• According to the [staging system + reference], there are [number] stages of [malignancy name] based on the [finding1], [finding2], and [finding3]. Each stage is assigned a [letter/number1] and a [letter/number2] that designate the [feature1] and [feature2].

OR

• The staging of [malignancy name] is based on the [staging system].

OR

• There is no established system for the staging of [malignancy name].