Primary biliary cirrhosis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]
Overview
Addison and Gull in 1851 described the clinical picture of progressive obstructive jaundice in the absence of mechanical obstruction of the large bile ducts. Ahrens et al in 1950 coined the term primary biliary cirrhosis for this disease. The association with anti mitochondrial antibodies was first reported in 1986.[1]
Historical Perspective
Discovery
- Primary biliary cirrhosis was first discovered by Addison and Gull, in 1851 in the Guys hospital report. It was being titled as "On a Certain Affectation of the Skin Vitiligoiidea-alpha plana, beta tuberosa"
- In 1892, Hanot reported on "La Cirrhosishypertrophiue avee ictere and chronique"
- The term "primary biliary cirrhosis was coined in 1950 by Ahrens et el.
References
- ↑ Mitchison HC, Bassendine MF, Hendrick A; et al. (1986). "Positive antimitochondrial antibody but normal alkaline phosphatase: is this primary biliary cirrhosis?". Hepatology. 6 (6): 1279–84. doi:10.1002/hep.1840060609. PMID 3793004.