Hypoaldosteronism pathophysiology

Hypoaldosteronism Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Pathophysiology

Hypoaldosteronism is defined as decreased levels of the hormone aldosterone (Normal range: 1-21 ng/dL). Hypoaldosteronism from decreased aldosterone synthesis can be due to :

• Adrenal Insufficiency: Primary or secondary
• Enzyme deficiency: Aldosterone synthase, 21 hydroxylase, and 11B hydroxylase
• Renal disorders: Chronic renal failure and diabetic nephropathy
• Drugs inhibiting aldosterone effect: NSAID, spironolactone, and triamterene