Hypoaldosteronism diagnostic criteria

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There is no established criteria for the diagnosis of hypoaldosteronism. A positive history of hypotension, muscle weakness and fatigue should raise suspicion for hypoaldosteronism.

Diagnostic Criteria

• There is no established criteria for the diagnosis of hypoaldosteronism. However, patients with suspected hypoaldosteronism should be tested for underlying conditions which can lead to decreased aldosterone level or aldosterone resistance such as diabetes, chronic kidney disease, serum mineralocorticoid, corticosteroid and androgen level. Hypoaldosteronism is usually discovered during routine laboratory evaluations. Patients with family history of hypoaldosteronism should also be checked for CYP11B2 (aldosterone synthase) and NR3C2 (mineralocorticoid receptor) gene mutations. Complete history should also be obtained regarding drug use which can affect aldosterone synthesis or function such as NSAID, ACEi, B blockers, heparin, calcineurin inhibitors.