Hypoaldosteronism laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

A positive history of hypotension, muscle weakness and fatigue should raise suspicion for hypoaldosteronism. An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal among patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

• Laboratory findings consistent with the diagnosis of hypoaldosteronism include:
  • Hyperkalemia
  • Mild anion gap metabolic acidosis
  • [abnormal test 3]

• Patients suspects of hypoaldosteronism shopuld be checked for plasma renin activity (PRA), serum aldosterone, and serum cortisol.
• The following table distinguishes among various subtypes of hypoaldosteronism:

Disorder	Plasma ReninActivity	Plasma Aldosterone	Plasma cortisol
Hyporeninemic hypoaldosteronism	Low	Low	Normal
Hypereninemic hypoaldosteronism	Increased	Low	Normal/↓
Primary adrenal insufficiency	High	Low	Low
Pseudohypoaldosteronism type I	High	High	Normal
Pseudohypoaldosteronism type II	Normal/↓	Normal/↓	Normal