Chorioamnionitis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Adnan Ezici, M.D[2]
Overview
Laboratory findings
Complete Blood Cell Count
Laboratory findings consistent with the diagnosis of chorioamnionitis include:[1]
- Maternal leukocytosis (> 12,000-15,000 per mm3)
- Left shift or elevated band count (> 9%)
Histology
Histologic findings consistent with the diagnosis of chorioamnionitis include:[2][3]
- Neutrophilic infiltration of chorioamniotic membranes
- Edema and necrosis of the amniotic epithelium (findings consistent with the necrotizing chorioamnionitis)
- Microabscesses involving the subchorionic fibrin
- Umbilical vasculitis with or without neutrophilic infiltration of Wharton's Jelly (acute funisitis)
Amniotic Fluid Testing
Amniotic fluid findings consistent with the diagnosis of chorioamnionitis include:[1]
- Positive microbiological culture results (diagnostic Gold standard (test)gold standard)
- Bacteria or white blood cells (> 6/HPF) on gram stain
- Decreased glucose level (< 15 mg/dl)
- Elevated IL-6 (> 7.9 ng/ml)
- Positive matrix metalloproteinase
- Elevated white blood cell count (> 30/cubic mm)
- Positive leukocyte esterase on dipstick
References
- ↑ 1.0 1.1 Tita AT, Andrews WW (June 2010). "Diagnosis and management of clinical chorioamnionitis". Clin Perinatol. 37 (2): 339–54. doi:10.1016/j.clp.2010.02.003. PMC 3008318. PMID 20569811.
- ↑ Kim CJ, Romero R, Chaemsaithong P, Chaiyasit N, Yoon BH, Kim YM (October 2015). "Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance". Am J Obstet Gynecol. 213 (4 Suppl): S29–52. doi:10.1016/j.ajog.2015.08.040. PMC 4774647. PMID 26428501.
- ↑ Aljerian K (2020). "Chorioamnionitis: Establishing a correlation between clinical and histological diagnosis". Indian J Pathol Microbiol. 63 (1): 44–48. doi:10.4103/IJPM.IJPM_464_19. PMID 32031121 Check
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