Growth hormone deficiency historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
In the mid-1940s, Li and Evans were the first to purify bovine GH. By 1985, GH extracted from human pituitary glands were used to treat growth hormone deficiency. In 1981, Genentech developed the first recombinant human GH. In 1981, Genentech developed the first recombinant human GH for the therapy of severe childhood GHD.
Historical Perspective
- In the mid-1940s, Li and Evans were the first to purify bovine GH at the University of California.[1]
- In 1956, Li and Papkoff were the first to isolate growth hormone from the human pituitary gland at California University.
- By 1985, GH extracted from human pituitary glands were used to treat growth hormone deficiency.[2]
- In 1985, treatment with GH extracts has been stopped completely due to reports of four young adults in the United States with Creuzfeldt Jacob Disease who had been treated with GH.[3]
- In 1981, Genentech developed the first recombinant human GH for the therapy of severe childhood GHD. [4]
- List of indications for GH use in non-GH-deficient children and adults have increased with time.[5]
References
- ↑ Frasier SD (1997). "The not-so-good old days: working with pituitary growth hormone in North America, 1956 to 1985". J Pediatr. 131 (1 Pt 2): S1–4. PMID 9255217.
- ↑ Franklin SL, Geffner ME (2009). "Growth hormone: the expansion of available products and indications". Endocrinol Metab Clin North Am. 38 (3): 587–611. doi:10.1016/j.ecl.2009.06.006. PMID 19717006.
- ↑ "Degenerative neurologic disease in patients formerly treated with human growth hormone. Report of the Committee on Growth Hormone Use of the Lawson Wilkins Pediatric Endocrine Society, May 1985". J Pediatr. 107 (1): 10–2. 1985. PMID 3891943.
- ↑ Flodh H (1986). "Human growth hormone produced with recombinant DNA technology: development and production". Acta Paediatr Scand Suppl. 325: 1–9. PMID 3296632.
- ↑ Takeda A, Cooper K, Bird A, Baxter L, Frampton GK, Gospodarevskaya E; et al. (2010). "Recombinant human growth hormone for the treatment of growth disorders in children: a systematic review and economic evaluation". Health Technol Assess. 14 (42): 1–209, iii–iv. doi:10.3310/hta14420. PMID 20849734.