Primary biliary cirrhosis classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aysha Anwar, M.B.B.S[2]
Overview
There is no established system for the classification of Primary biliary cirrhosis. However, it can be classified into four stages depending on the histology of the disease.[1]
Classification
- There is no established system for the classification of primary biliary cirrhosis.
- However, it can be classified into four stages according to histological classification of Ludwig. According to Ludwig classification, all four stages may be present on a single liver biopsy.[1][2]
- It can also be classified into four stages according to the histological classification of P. Scheuer.[3]
| Classification of Primary biliary cirrhosis on the basis of histology | |
|---|---|
| Ludwig classification | |
| Stage | Histologic |
| Stage 0 | Normal liver |
| Stage 1 | Stage 1 is characterized by portal inflammation |
| Stage 2 | Extension of inflammation beyond portal tracts into surrounding parenchyma with or without ductal loss |
| Stage 3 | There is presence of fibrous septa linking adjacent portal tracts |
| Stage 4 | Stage 4 is characterized by cirrhosis |
| Scheuer's classification | |
| Stage 1 | florid duct lesion or chronic non-suppurative destructive cholangitis |
| Stage 2 | proliferation of the small bile ductules |
| Stage 3 | fibrosis or scarring |
| Stage 4 | cirrhosis |
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References
- ↑ 1.0 1.1 Lindor KD, Gershwin ME, Poupon R, Kaplan M, Bergasa NV, Heathcote EJ; et al. (2009). "Primary biliary cirrhosis". Hepatology. 50 (1): 291–308. doi:10.1002/hep.22906. PMID 19554543.
- ↑ Ludwig J, Dickson ER, McDonald GS (1978). "Staging of chronic nonsuppurative destructive cholangitis (syndrome of primary biliary cirrhosis)". Virchows Arch A Pathol Anat Histol. 379 (2): 103–12. PMID 150690.
- ↑ Scheuer P (1967). "Primary biliary cirrhosis". Proc R Soc Med. 60 (12): 1257–60. PMC 1901478. PMID 6066569.