Autoimmune hepatitis classification
|
Autoimmune hepatitis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Autoimmune hepatitis classification On the Web |
|
American Roentgen Ray Society Images of Autoimmune hepatitis classification |
|
Risk calculators and risk factors for Autoimmune hepatitis classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: ;Manpreet Kaur, MD [2]
Overview
Classification
According to European Association for the Study of the Liver, there are three types of Autoimmune hepatitis discussed below:
- AIH-1:
- Common type of AIH (accounts almost for 90% of AIH cases)
- Presents at any age
- Detection of ANA, SMA
or anti-SLA/LP;
- Association with HLA DR3, DR4, and DR13; any age at onset of variable clinical and
histopathological severity; rare failure of treatment but variable relapse rates after drug withdrawal and variable need for long-term maintenance therapy • AIH-2: accounts for up to 10% of AIH cases; detection of anti-LKM1, anti-LC1 and rarely anti- LKM3; association with HLA DR3 and DR7; onset usually in childhood and young adulthood; clinical and histopathological severity commonly acute and advanced; frequent failure of treatment and frequent relapse rates after drug withdrawal; the need for long-term maintenance therapy very common • AIH-3: SLA/LP positive, otherwise very similar to AIH-1; often Ro52-antibody positive. Possibly more severe