Multiple sclerosis causes
|
Multiple sclerosis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Multiple sclerosis causes On the Web |
|
American Roentgen Ray Society Images of Multiple sclerosis causes |
|
Risk calculators and risk factors for Multiple sclerosis causes |
Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing. Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
Multiple sclerosis may be caused by:
Autoimmunity:
The main hypothesis regarding MS etiology is that it is caused by an autoimmune reaction against central nervous system (CNS). Self reactive T cells which has been activated by a foreign (virus for example) or native factor, will attack the myelin sheath around the neurons. [1] Presents of autoreactive T cells and myelin basic protein-specific CD4+ T cells in the peripheral blood smear of MS patients supports the autoimmune hypothesis. [2] [3]
Genetic:
Infectious:
Degenerative:
References
- ↑ Korn T (2008). "Pathophysiology of multiple sclerosis". J. Neurol. 255 Suppl 6: 2–6. doi:10.1007/s00415-008-6001-2. PMID 19300953.
- ↑ Pette M, Fujita K, Kitze B, Whitaker JN, Albert E, Kappos L, Wekerle H (1990). "Myelin basic protein-specific T lymphocyte lines from MS patients and healthy individuals". Neurology. 40 (11): 1770–6. PMID 1700336.
- ↑ Bielekova B, Goodwin B, Richert N, Cortese I, Kondo T, Afshar G, Gran B, Eaton J, Antel J, Frank JA, McFarland HF, Martin R (2000). "Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand". Nat. Med. 6 (10): 1167–75. doi:10.1038/80516. PMID 11017150.