Sinusoidal obstruction syndrome medical therapy

Sinusoidal obstruction syndrome Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Medical Therapy

• The management of sinusoidal obstruction syndrome depends on the severity of the disease.
• Supportive care is the mainstay of treatment.
• Supportive measures include:
  • Maintaining intravascular volume
  • Avoidance of hepatotoxic agents
  • Paracentesis can be done to remove ascitic fluid
  • Narcotics can be used to keep patient pain free.
• Patients with mild to moderate sinusoidal obstruction syndrome can be treated with supportive care alone. However, severe cases need defibrotide (thrombolytic agent) along with supportive care.