Idiopathic pulmonary fibrosis pathophysiology

Idiopathic pulmonary fibrosis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Pathophysiology

Normal lung tissue

• Lungs are composed normally of extracellular collagen which allows the lungs to exert their breathing efforts.
• Different collagen types in the lung include the following:
  • Type 1 and type 3 compose most of the lung tissue
  • Type 2 is the main component of the cartilage of the main bronchi
  • Type 4 forms the basement membrane
  • Type 5 forms the interstitial tissue