Eosinophilic pneumonia causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2]
Overview
Causes of eosinophilic lung diseases are acute eosinophilic pneumonia, chrnoic eosinophilic pneumonia, tropical pulmonary eosinophilia, eosinophilic granulomatosis with polyangitis, allergic bronchopulmonary aspergillosis, and medications such as nonsteroidal anti-inflammatory drugs, Anticonvulsants, Antidepressants, Angiotensin converting enzyme inhibitors, and Beta blockers.
Causes
Acute eosinophilic pneumonia (AEP)
- The cause of acute eosinophilic pneumonia is unknown but an acute hypersensitivity reaction is suggested.[1]
Chrnoic eosinophilic pneumonia (CEP)
- Chronic eosinophilic pneumonia is an characterized by an abnormal and marked accumulation of eosinophils in the interstitium and alveolar spaces of the lung.[2]
Transpulmonary passage of helminth larvae (Löffler syndrome)
- Three types of helminths, Ascaris, hookworms, and Strongyloides stercoralis, have larvae that reach the lungs, penetrate into alveoli, and ascend the airways then reach the gastrointestinal tract.
- Ascaris is the most common cause of Löffler syndrome worldwide.[3][4]
Tropical pulmonary eosinophilia
- Tropical pulmonary eosinophilia is immune response to the lymphatic filariae and Wuchereria bancrofti.[5]
- Pulmonary function tests may show a mixed restrictive and obstructive abnormality with a reduction in diffusion capacity.[6]
Eosinophilic granulomatosis with polyangitis
- Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) is a vasculitic disorder often characterized by sinusitis, asthma, and prominent peripheral blood eosinophilia.[7]
- It is the sole form of vasculitis that is associated with both eosinophilia and frequent lung involvement.
- In addition to the lungs, the skin and the cardiovascular, gastrointestinal, renal, and neurologic systems may also be involved.
Allergic bronchopulmonary aspergillosis
- Allergic bronchopulmonary aspergillosis is a complex hypersensitivity reaction that occurs when airways become colonized by Aspergillus.[8]
- Immunologic responses elicited by Aspergillus fumigatus are responsible for this syndrome. It can lead to bronchiectasis, and fibrosis.
Drugs and toxins
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a drug-induced hypersensitivity reaction that includes skin eruption, eosinophilia, atypical lymphocytosis, lymphadenopathy, and kidney involvement. Drugs causing DRESS are:[9]
- Nonsteroidal anti-inflammatory drugs
- Anticonvulsants
- Antidepressants
- Angiotensin converting enzyme inhibitors
- Beta blockers
- Hydrochlorothiazide
- Cocaine[10]
References
- ↑ Cottin V (2016). "Eosinophilic Lung Diseases". Clin Chest Med. 37 (3): 535–56. doi:10.1016/j.ccm.2016.04.015. PMID 27514599.
- ↑ Yıldız T, Dülger S (2018). "Non-astmatic Eosinophilic Bronchitis". Turk Thorac J. 19 (1): 41–45. doi:10.5152/TurkThoracJ.2017.17017. PMC 5783052. PMID 29404185.
- ↑ . PMID 13331628. Missing or empty
|title=(help) - ↑ Yang Z, Lei W, Xiao-Li L, Xiao-Jun T, Wei L, Yi-Jun A; et al. (2017). "[Clinical features of imported schistosomiasis mansoni in Beijing City：a report of 6 cases]". Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 29 (2): 150–154. doi:10.16250/j.32.1374.2016207. PMID 29469316.
- ↑ . PMID 15486834. Missing or empty
|title=(help) - ↑ Jai B. Mullerpattan, Zarir F. Udwadia & Farokh E. Udwadia (2013). "Tropical pulmonary eosinophilia--a review". The Indian journal of medical research. 138 (3): 295–302. PMID 24135173. Unknown parameter
|month=ignored (help) - ↑ L. Guillevin, P. Cohen, M. Gayraud, F. Lhote, B. Jarrousse & P. Casassus (1999). "Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients". Medicine. 78 (1): 26–37. PMID 9990352. Unknown parameter
|month=ignored (help) - ↑ . PMID 16612769. Missing or empty
|title=(help) - ↑ Peter W. Kim, Alfred F. Sorbello, Ronald T. Wassel, Tracy M. Pham, Joseph M. Tonning & Sumathi Nambiar (2012). "Eosinophilic pneumonia in patients treated with daptomycin: review of the literature and US FDA adverse event reporting system reports". Drug safety. 35 (6): 447–457. doi:10.2165/11597460-000000000-00000. PMID 22612850. Unknown parameter
|month=ignored (help) - ↑ Reyes F, Vaitkus V, Al-Ajam M (2018). "A case of cocaine-induced eosinophilic pneumonia: Case report and review of the literature". Respir Med Case Rep. 23: 98–102. doi:10.1016/j.rmcr.2017.12.012. PMC 5805849. PMID 29487790.