Ankylosing spondylitis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There is no known cause specific cause for ankylosing spondylitis, though genetic factors seems to play very important role in developing the disease. In particular, people who are positive for HLA-B27 are at more risk of developing ankylosing spondylitis.Ankylosing spondylitis is a form of chronic joint inflammation that mostly affects the spine. Gradually it can cause the bones of the spine to fuse together, a process which is called ankylosis.

Risk Factors

• The most potent risk factor in the development of ankylosing spondylitis is positive for HLA-B27. Other risk factors include environmental, gender, and age.