Ankylosing spondylitis epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Vamsikrishna Gunnam M.B.B.S [2]
Overview
The prevalence of axial spondyloarthritis (axSpA) or ankylosing spondylitis in a population depends upon the following 1)Ethnic groups 2) Selection of subjects for evaluation and 3) The criteria for diagnosis.It shows a clear evidence that correlation between the prevalence of ankylosing spondylitis (AS)/axial spondyloarthritis (axSpA) in a given population and the prevalence of human leukocyte antigen HLA-B27 exits.
Epidemiology and Demographics
Prevalence
- The prevalence of ankylosing spondylitis is approximately 7-490 per 100,000 individuals worldwide.[1][2]
- In the year 2009, according to National Health and Nutrition Examination Survey (NHANES) the incidence of ankylosing spondylitis was estimated to be 6.1% cases per 100,000 individuals worldwide.
Incidence[3][4][5]
- The incidence of ankylosing spondylitis is approximately 7.26 per 100,000 persons in the adult population
- The incidence of fractures in ankylosing spondylitis is approximately 4 to 18 percent .
- The incidence of ankylosing spondylitis is approximately 6–7 per 100,000 persons in caucasian populations.
Mortality rate [6][7]
- The mortality rate of ankylosing spondylitis is approximately was 1.60 (95% CI 1.44-1.77).
- The mortality rate of ankylosing spondylitis increased mostly because of circulatory disease that associated with ankylosing spondylitis.
Age[8][9]
- The incidence of ankylosing spondylitis increases with age; the median age at diagnosis is second and third decades of life years.
- Mostly 80% of the patients with ankylosing spondylitis(AS) experience symptoms at ≤ 30 years of age, But only 5% will present with symptoms at ≥ 45 years of age.
Race[10]
- Ankylosing spondylitis(AS) usually affects individuals of the North America race. Japan individuals are less likely to develop ankylosing spondylitis(AS).
Gender[11]
- Men are more commonly affected by Ankylosing spondylitis(AS) than women. The men to women ratio is approximately 2:1.
References
- ↑ Reveille JD, Weisman MH (June 2013). "The epidemiology of back pain, axial spondyloarthritis and HLA-B27 in the United States". Am. J. Med. Sci. 345 (6): 431–6. PMC 4122314. PMID 23841117.
- ↑ Bakland, Gunnstein; Nossent, Hans C.; Gran, Jan T. (2005). "Incidence and prevalence of ankylosing spondylitis in Northern Norway". Arthritis & Rheumatism. 53 (6): 850–855. doi:10.1002/art.21577. ISSN 0004-3591.
- ↑ Mundwiler ML, Siddique K, Dym JM, Perri B, Johnson JP, Weisman MH (2008). "Complications of the spine in ankylosing spondylitis with a focus on deformity correction". Neurosurg Focus. 24 (1): E6. doi:10.3171/FOC/2008/24/1/E6. PMID 18290744.
- ↑ Bakland, Gunnstein; Nossent, Hans C.; Gran, Jan T. (2005). "Incidence and prevalence of ankylosing spondylitis in Northern Norway". Arthritis & Rheumatism. 53 (6): 850–855. doi:10.1002/art.21577. ISSN 0004-3591.
- ↑ Vosse D, Feldtkeller E, Erlendsson J, Geusens P, van der Linden S (October 2004). "Clinical vertebral fractures in patients with ankylosing spondylitis". J. Rheumatol. 31 (10): 1981–5. PMID 15468363.
- ↑ Oh JS, Doh JW, Shim JJ, Lee KS (June 2016). "Leading a Patient of Ankylosing Spondylitis to Death by Iatrogenic Spinal Fracture". Korean J Spine. 13 (2): 80–2. doi:10.14245/kjs.2016.13.2.80. PMC 4949174. PMID 27437020.
- ↑ Bakland G, Gran JT, Nossent JC (November 2011). "Increased mortality in ankylosing spondylitis is related to disease activity". Ann. Rheum. Dis. 70 (11): 1921–5. doi:10.1136/ard.2011.151191. PMID 21784726.
- ↑ Pradeep, D. J.; Keat, A.; Gaffney, K. (2008). "Predicting outcome in ankylosing spondylitis". Rheumatology. 47 (7): 942–945. doi:10.1093/rheumatology/ken195. ISSN 1462-0324.
- ↑ Montilla C, Del Pino-Montes J, Collantes-Estevez E, Font P, Zarco P, Mulero J, Gratacós J, Rodríguez C, Juanola X, Fernández-Sueiro JL, Almodovar R (May 2012). "Clinical features of late-onset ankylosing spondylitis: comparison with early-onset disease". J. Rheumatol. 39 (5): 1008–12. doi:10.3899/jrheum.111082. PMID 22422491.
- ↑ Reveille JD (April 2011). "Epidemiology of spondyloarthritis in North America". Am. J. Med. Sci. 341 (4): 284–6. doi:10.1097/MAJ.0b013e31820f8c99. PMC 3063892. PMID 21430444.
- ↑ Pradeep, D. J.; Keat, A.; Gaffney, K. (2008). "Predicting outcome in ankylosing spondylitis". Rheumatology. 47 (7): 942–945. doi:10.1093/rheumatology/ken195. ISSN 1462-0324.