Cryoglobulinemia history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2]Feham Tariq, MD [3]
Overview
History
Patients having cryoglobulinemia may have positive history of:
- Hepatitis C infection
- Hepatitis B infection
- Leg ulcers
Symptoms
Symptoms vary depending on the type of cryoglobulinemia and the organs involved. Symptoms of cryoglobulinemia may include:
Pulmonary symptoms:
- Difficulty breathing and cough
Renal symptoms:
- Renal involvement is more common in type II than in type III.
- Nephrotic range proteinuria with edema
Cutaneous symptoms:
Gastrointestinal symptoms
- Abdominal pain
General symptoms:
- Nonspecific constitutional symptoms
- Fever
- Arthralgia, specifically affecting metacarophangeal, proximal phalangeal, knees and ankles. It worsens with exposure to the cold.
- Myalgia
- Fatigue