Cryoglobulinemia natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Feham Tariq, MD [2]
Overview
Natural History
Complications
The complications of cryoglobulinemia are as follows:
- Rapidly progressive neuropathy
- Heart failure
- Digital ischemia threatening amputation
- Diffuse alveolar hemorrhage resulting in hemoptysis
- Respiratory failure
- Stroke
Prognosis
Patients having severe manifestations of the disease such as pulmonary vasculitis, end-stage renal disease, cardiac vasculitis and central nervous system vascultitis have generally poor prognosis of the disease. The prognosis of cryoglobulinemia depends on the organ system involved and varies accordingly.
Organ system involved | Survival rate |
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Glomerulonephritis | 79% |
Pulmonary vasculitis | 22% |
Central nervous system vasculitis | 66% |
Gastrointestinal vasculitis | 67% |
Cardiac vasculitis | 100% |