Hyponatremia historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Saeedeh Kowsarnia M.D.[2]

Overview

In 1858,Claude Bernard, French physiologist first proposed a direct relationship between the central nervous system and renal excretion of osmotically active solutes ^[1].
In 1913,Jungmann and Meyer in Germany induced polyuria and increased urinary salt excretion in animals through medullary lesion .
in 1950,Peters, Welt, and co-workers described few patients with encephalitis, hypertensive intracranial hemorrhage, and bulbar poliomyelitis who presented with severe dehydration and hyponatremia .

[Disease name] was first discovered by [name of scientist], a [nationality + occupation], in [year]/during/following [event].

The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].

There have been several outbreaks of [disease name], which are summarized below:

In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].

↑ J. Barcroft & H. Straub (1910). "The secretion of urine". The Journal of physiology. 41 (3–4): 145–167. PMID 16993045. Unknown parameter |month= ignored (help)