Rapidly progressive glomerulonephritis physical examination

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

Physical examination

Appearance of the patient

  • Patients with rapidly progressive glomerulonephritis usually appear ill.

Vital signs

  • Hypertension

Skin

  • Leukocytoclastic vasculitis[1]
  • Erythematous nodules due to necrotizing arteritis
  • Granulomatous cutaneous nodules in patients present with granulomatosis with polyangitis

Abdomen

  • Most of patients with ANCA +ve shows gastrointestinal involvement[2]
  • Occult GI bleeding as a result of ulceration due to arteritis
  • Pancreatitis may be present

Neuromuscular

  • Mononeuritis multiplex in ANCA +ve patients[3]
  • Arthritis
  • Arthralgia

Genitourinary

  • Hematuria

References

  1. Daoud MS, Gibson LE, DeRemee RA, Specks U, el-Azhary RA, Su WP (October 1994). "Cutaneous Wegener's granulomatosis: clinical, histopathologic, and immunopathologic features of thirty patients". J. Am. Acad. Dermatol. 31 (4): 605–12. PMID 8089286.
  2. Pagnoux C, Mahr A, Cohen P, Guillevin L (March 2005). "Presentation and outcome of gastrointestinal involvement in systemic necrotizing vasculitides: analysis of 62 patients with polyarteritis nodosa, microscopic polyangiitis, Wegener granulomatosis, Churg-Strauss syndrome, or rheumatoid arthritis-associated vasculitis". Medicine (Baltimore). 84 (2): 115–28. PMID 15758841.
  3. Anadure R, Narayanan C, Varadraj G, Nandeesh B (January 2017). "ANCA Associated Mononeuritis Multiplex with Overlap in Vasculitic Syndromes". J Clin Diagn Res. 11 (1): OD01–OD03. doi:10.7860/JCDR/2017/22252.9149. PMC 5324437. PMID 28273992.

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