Paroxysmal nocturnal hemoglobinuria laboratory findings

Paroxysmal nocturnal hemoglobinuria Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

An elevated/reduced concentration of serum/blood/urinary/CSF/other [lab test] is diagnostic of [disease name].

OR

Laboratory findings consistent with the diagnosis of [disease name] include [abnormal test 1], [abnormal test 2], and [abnormal test 3].

OR

[Test] is usually normal for patients with [disease name].

OR

Some patients with [disease name] may have elevated/reduced concentration of [test], which is usually suggestive of [progression/complication].

OR

There are no diagnostic laboratory findings associated with [disease name].

Laboratory Findings

Laboratory findings consistent with the diagnosis of [PNH] include:

• Due to hemolysis
  1. low hemoglobin
  2. low RBC count
  3. increased reticulocyte count
  4. increased LDH
  5. increased bilirubin
  6. decreased haptoglobin
  7. haemoglobinuria
  8. negative coombs/ direct anti-globulin test

• Due to haemoglobinuria
  1. urinalysis: positive dipstick for heme with negative microscopic analysis for RBC
  2. increased creatinine
  3. increased BUN
  4. iron deficiency: low iron, low ferritin, increased transferrin/ TIBC

• Due to thrombosis
  1. thrombocytopenia
  2. elevated liver function tests