Leiomyosarcoma causes
Overview:
Leimoyosarcoma is a very rare disease which involves uterine.
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Causes:
Exact cause of leiomyosarcoma is not clearly unerstood, however following points are considered regarding causes[1]:
- Although not proven but some reasearchers believes that it could be a malignant transformation of the fibroid( leiomyoma).
- It may arise denovo or can be due to the genomic instability. However molecular mechanism of tumorigenesis driven by genomic and genetic aberration is yet to be elucidated.
- Over expression of the protooncogene C-myc is seen in 50% of the cases.
- Retinobalstoma gene discrepancies are also seen in 90% of cases.
- P16 chromosomal deletion causes loss of tumor suppression and so is involved in the development of leiomyosarcoma.
- P53 gene mutation is also frequently seen in uterine leiomyosarcoma.
References
- ↑ Crystal JS, Korderas K, Schwartzberg D, Tizio SC, Zheng M, Parker G (2018). "Primary Leiomyosarcoma of the Colon: A Report of Two Cases, Review of the Literature, and Association with Immunosuppression for IBD and Rheumatoid Arthritis". Case Rep Surg. 2018: 6824643. doi:10.1155/2018/6824643. PMC 5892970. PMID 29780656.