Paroxysmal nocturnal hemoglobinuria historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

In the 19th century, the European physicians conducted observational studies which resulted in the establishment of Paroxysmal Nocturnal Hemoglobinuria (PNH) as a separate disease from paroxysmal cold hemoglobinuria and march hemoglobinuria.
In 1815, Dr. Paul Strübing, a German physician, was the first to put the hypothesis of PNH. The hypothesis mentioned the abnormal hemolysis of the red blood cells due to increased plasma acidity in the night time.^[1]^[2]
Dr. Paul returned the abnormal hemolysis of the RBCs due to increased carbon dioxide gas as a result of the slow circulation nocturnally.
In 1911, Dr. Ettore Marchiafava and Dr. Alessio Nazari added a more description about PNH.^[3]
In

↑ Strübing P. Paroxysmale Hämoglobinurie. Dtsch Med Wochenschr 1882;8:1-3 and 17-21.
↑ Whonamedit entry
↑ Marchiafava E, Nazari A. Nuovo contributo allo studio degli itteri cronici emolitici. Policlinico [Med] 1911;18:241-254.