Focal segmental glomerulosclerosis historical perspective

Focal segmental glomerulosclerosis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [3], Manpreet Kaur, MD [4], Olufunmilola Olubukola M.D.[5]

Overview

Focal segmental glomerulosclerosis (FSGS) was discovered by Theodor Fahr, a German pathologist, in 1925, and he referred to it as "lipoid nephrosis with degeneration", showing a clear association to minimal change disease. In 1957, FSGS was then described by Dr. Arnold Rich, a pathologist at Johns Hopkins University.

Historical Perspective

Discovery

• Focal segmental glomerulosclerosis (FSGS) was first discovered by Theodor Fahr, a German pathologist, in 1925.
• He referred to it as "lipoid nephrosis with degeneration", showing a clear association to minimal change disease.
• In 1957, FSGS was then described by Dr. Arnold Rich, a pathologist at Johns Hopkins University.
• In 1970, Jacob Churg and colleagues finally classified FSGS as a unique renal glomerulopathy in the " Pathology of the Nephrotic Syndrome in Children: Report for the International Study of Kidney Disease in Children" in view of its clinical and pathological features, and its steroid-resistance in comparison to minimal change disease.