Sideroblastic anemia causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nazia Fuad M.D.
Overview
There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated sideroblastic anemia is common.Common causes of sideroblastic anemia may include, alcoholism, chloramphenicol, isoniazid, copper deficiency (nutritional, zinc-induced, copper chelation), vit B-6 deficiency, X-linked sideroblastic anemia. Less common causes of sideroblastic anemia include myelodysplastic syndrome, autosomal recessive disorders, X-linked sideroblastic anemia. defect in ALAS2, autosomal recessive sideroblastic anemia with mutations in the SLC25A38 gene and genetic syndromes.
Causes
Life-threatening Causes
- There are no life-threatening causes of sideroblastic anemia, however complications resulting from untreated sideroblastic anemia are common.
Common Causes
Common causes of sideroblastic anemia may include:[1][2]
- Alcoholism
- Chloramphenicol
- Isoniazid
- Copper deficiency (nutritional, zinc-induced, copper chelation)
- Vit B-6 deficiency
- X-linked sideroblastic anemia
Less Common Causes
Less common causes of sideroblastic anemia include:
Genetic Causes
- X-linked sideroblastic anemia. defect in ALAS2.[3]
- Autosomal recessive sideroblastic anemia with mutations in the SLC25A38 gene.
- Genetic syndromes
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | Lead poisoning, zinc |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Chloramphenicol,Isoniazid
cycloserine, linezolid, |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | X-linked sideroblastic anemia.
Autosomal recessive sideroblastic . Genetic syndromes |
| Hematologic | Myelodysplastic syndrome |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | Vit B-6 deficiency |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | Alcohol |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
List the causes of the disease in alphabetical order:
- Alcohol
- Vit B-6 def
- Chloromphenicol
- Copper deficiency
- Cause 5
- Cause 6
- Cause 7
- Cause 8
- isoniazid
- Cause 10
References
- ↑ Cazzola M, Invernizzi R (June 2011). "Ring sideroblasts and sideroblastic anemias". Haematologica. 96 (6): 789–92. doi:10.3324/haematol.2011.044628. PMC 3105636. PMID 21632840.
- ↑ Bottomley SS, Fleming MD (August 2014). "Sideroblastic anemia: diagnosis and management". Hematol. Oncol. Clin. North Am. 28 (4): 653–70, v. doi:10.1016/j.hoc.2014.04.008. PMID 25064706.
- ↑ Long Z, Li H, Du Y, Han B (August 2018). "Congenital sideroblastic anemia: Advances in gene mutations and pathophysiology". Gene. 668: 182–189. doi:10.1016/j.gene.2018.05.074. PMID 29787825.