Kaposi's sarcoma differential diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

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Overview

Kaposi's sarcoma must be differentiated from other diseases that cause similar cutaneous, pulmonary, and gastrointestinal involvement, such as bacillary angiomatosis, AIDS-related lymphoma, and seborrheic keratosis.

Differentiating Kaposi's Sarcoma from other Diseases

• Kaposi's sarcoma must be differentiated from other diseases that cause similar cutaneous, pulmonary, and gastrointestinal involvement, such as:

• Kaposi's sarcoma cutaneous lesions must be differentiated from:

• Bacillary angiomatosis
• Arteriovenous malformation
• Acroangiodermatitis
• Masson's hemangioma
• Angiosarcoma
• Seborrheic keratosis
• Erythematous lupus
• Pigmented purpuric dermatosis
• Pyogenic granuloma
• Benign lymphangioendothelioma
• Cavernous hemangioma
• Sarcomatoid carcinoma
• Spindle cell hemangioendothelioma

• Kaposi's sarcoma pulmonary lesions must be differentiated from:

• AIDS-related lymphoma
• Atypical pneumonia
• Fungal or mycobacterial infection
• Lung cancer

• Kaposi's sarcoma gastrointestinal lesions must be differentiated from:

• Peptic ulcer disease
• Inflammatory bowel disease (IBD)
• Gastrointestinal tract cancer

Diseases	Etiology	Clinical manifestations						Para-clinical findings							Gold standard	Additional findings
		Symptoms			Physical examination
								Lab Findings			Imaging			Histopathology
		Skin lesions	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2	Imaging 3
Bacillary angiomatosis
Arteriovenous malformation
Acroangiodermatitis
Diseases		Symptom 1	Symptom 2	Symptom 3	Physical exam 1	Physical exam 2	Physical exam 3	Lab 1	Lab 2	Lab 3	Imaging 1	Imaging 2	Imaging 3	Histopathology	Gold standard	Additional findings
Angiosarcoma
Masson's hemangioma
Seborrheic keratosis
Erythematous lupus
Pigmented purpuric dermatosis
Pyogenic granuloma
Benign lymphangioendothelioma
Cavernous hemangioma
Sarcomatoid carcinoma
Spindle cell hemangioendothelioma