Paroxysmal nocturnal hemoglobinuria history and symptoms

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Paroxysmal nocturnal hemoglobinuria Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

History and Symptoms

History

Patients with PNH may have a positive history of:

  • Feeling tired/ weak
  • Shortness of breath
  • Dark colored urine
  • Jaundice
  • Blood clots
  • Difficulty swallowing
  • Chest pain
  • Abdominal pain
  • Headaches
  • Confusion
  • Dysphagia
  • Erectile dysfunction
  • Low blood cell counts
  • Iron deficiency

Common Symptoms

Common symptoms of PNH include:

  • Due to hemolysis
    1. Fatigue
    2. Dyspnea
    3. Jaundice
  • Due to thrombosis:
    1. Headaches
    2. Confusion
    3. Abdominal pain
    4. Chest pain

Less Common Symptoms

Less common symptoms of PNH include:

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