Endometrial cancer classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Overview
Endometrial cancer may be classified according to histology into either type I comprising 80% of endometrial cancers or type II accounting for around 20%.
Classification
Endometrial cancer may be classified according to histology into 2 types:
| Type | Histology | Prognosis | Pathogenesis | Prevalence |
|---|---|---|---|---|
| Type I | Endometroid (adenocarcinoma) | Favorable (estrogen-responsive) | • May arise from atypical hyperplasia • Linked to unopposed estrogen stimulation |
80% |
| Type II | • Endometroid • Serous • Clear cell • Mucinous • Squamous • Mesonephric • Undifferentiated |
Typically bad prognosis | • Develops from atrophic endometrium • Not linked to hormonally driven pathogenesis |
15-20% |