Multiple sclerosis historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.,
Overview
Multiple sclerosis was first described by a neurologist, Dr. Jean Martin Charcot in 1868 and named sclerose en plaque. The signs and symptoms including dysarthria, ataxia, and tremor were called 'Charcot’s triad'.
Historical Perspective
Discovery
- Multiple sclerosis was first described by a neurologist, Dr. Jean martin Charcot in 1868.
- Previously, Dr. Robert Hooper (1773-1835), Robert Carswell (1793-1857), and Jean Cruveilhier (1791-1873) had noticed some of the MS clinical manifestations, but for the first time, Dr. Charcot described it as a distinct disease and named sclerose en plaque.
- The signs and symptoms including dysarthria, ataxia, and tremor, were called charcot’s triad by Dr. Charcot for the first time.
Landmark Events in the Development of Treatment Strategies
Famous Cases
- One of the first suspected MS patients in history is Saint Lidwina (1380-1433). She had symptoms such as pain, lower extremities weakness, and vision loss.[1][2]
- The other MS suspected patient in history is Augustus Frederick d’este (1794-1848). His symptoms began at the age of 28 with vision loss, bladder dysfunction, numbness, weakness of legs and sexual dysfunction.[3]
References
- ↑ Charcot, J. Histologie de la sclerose en plaques. Gazette des hopitaux, Paris, 1868; 41: 554–555.
- ↑ Poser C (1994). "The dissemination of multiple sclerosis: a Viking saga? A historical essay". Ann. Neurol. 36 Suppl 2: S231–43. PMID 7998792.
- ↑ Firth, D (1948). The Case of August D`Esté. Cambridge: Cambridge University Press.