Folate deficiency causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Kiran Singh, M.D. [2] Luke Rusowicz-Orazem, B.S.

Overview

Common causes of folate deficiency include gastrointestinal conditions, including malabsorption syndrome and other diseases obstructing folate absorption. Oncological causes, including leukemia, stomach cancer, and liver cancer are life threatening and should be promptly differentiated and diagnosed.^[1]

Causes^[2]^[3]^[4]^[5]^[6]^[7]

A deficiency of folate can occur when your need for folate is increased, when dietary intake of folate is inadequate, and when your body excretes (or loses) more folate than usual. Medications that interfere with your body's ability to use folate may also increase the need for this vitamin. Some research indicates that exposure to ultraviolet light, including the use of tanning beds, can lead to a folic acid deficiency.

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular	No underlying causes
Chemical/Poisoning	Alcoholism, Cycloserine, Daraprim, Ethanol, Ethotoin, Maloprim, Metformin, Methotrexate
Dental	No underlying causes
Dermatologic	Exfoliative dermatitis, Psoriasis
Drug Side Effect	Phenytoin, Primidone, Pyrimethamine, Seromycin pulvules, Sulfamethoxazole, Sulfasalazine , Sulphasalazine, Triamterene , Trimethoprim
Ear Nose Throat	No underlying causes
Endocrine	Enzyme defects, Hyperthyroidism
Environmental	No underlying causes
Gastroenterologic	Bacterial overgrowth of small intestine, Blind loop syndrome, Celiac disease, Congenital impairment of folic acid metabolism, Crohn's disease, Infiltrative bowel disease, Inflammatory bowel disease, Liver disease, Malabsorption syndrome, Malnutrition, Postoperative, Short bowel syndrome, Ulcerateive colitis, Vegetarianism
Genetic	No underlying causes
Hematologic	Anemia, Chronic blood loss, Chronic hemolytic anemia, Leukemia, Macrocytic anemia
Iatrogenic	Postoperative
Infectious Disease	No underlying causes
Musculoskeletal/Orthopedic	No underlying causes
Neurologic	No underlying causes
Nutritional/Metabolic	Congenital impairment of folic acid metabolism, Malnutrition, Overcooked foods, Poor dietary intake, Vegetarianism
Obstetric/Gynecologic	Lactation, Pregnancy
Oncologic	Leukemia, Paraneoplastic syndrome, Solid tumors
Ophthalmologic	No underlying causes
Overdose/Toxicity	Alcoholism, Substance abuse, Tobacco smoking
Psychiatric	No underlying causes
Pulmonary	No underlying causes
Renal/Electrolyte	Kidney dialysis
Rheumatology/Immunology/Allergy	Celiac disease, Crohn's disease, Cystic fibrosis , Psoriasis
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Advanced age

Causes in Alphabetical Order

3

References

↑ Green R, Datta Mitra A (2017). "Megaloblastic Anemias: Nutritional and Other Causes". Med Clin North Am. 101 (2): 297–317. doi:10.1016/j.mcna.2016.09.013. PMID 28189172.
↑ Oakley GP Jr, Adams MJ, Dickinson CM (1996). "More folic acid for everyone, now". Journal of Nutrition. 126 (3): 751S–755S. PMID 8598560.
↑ McNulty H (1995). "Folate requirements for health in different population groups". British Journal of Biomedical Science. 52 (2): 110–9. PMID 8520248.
↑ Stolzenberg R (1994). "Possible folate deficiency with postsurgical infection". Nutrition in Clinical Practice. 9 (6): 247–50. PMID 7476802.
↑ Pietrzik KF and Thorand B (1997). "Folate economy in pregnancy". Nutrition. 13 (11–12): 975–7. PMID 9433714.
↑ Kelly GS (1998). "Folates: Supplemental forms and therapeutic applications". Altern Med Rev. 3 (3): 208–20. PMID 9630738.
↑ Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, Mira FC (1996). "Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status". The American journal of clinical nutrition. 63 (2): 220–4. PMID 8561063.

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[pmid28189172-1] Green R, Datta Mitra A (2017). "Megaloblastic Anemias: Nutritional and Other Causes". Med Clin North Am. 101 (2): 297–317. doi:10.1016/j.mcna.2016.09.013. PMID 28189172.

[Oldref_6-2] Oakley GP Jr, Adams MJ, Dickinson CM (1996). "More folic acid for everyone, now". Journal of Nutrition. 126 (3): 751S–755S. PMID 8598560.

[Oldref_15-3] McNulty H (1995). "Folate requirements for health in different population groups". British Journal of Biomedical Science. 52 (2): 110–9. PMID 8520248.

[Oldref_16-4] Stolzenberg R (1994). "Possible folate deficiency with postsurgical infection". Nutrition in Clinical Practice. 9 (6): 247–50. PMID 7476802.

[Oldref_18-5] Pietrzik KF and Thorand B (1997). "Folate economy in pregnancy". Nutrition. 13 (11–12): 975–7. PMID 9433714.

[Oldref_19-6] Kelly GS (1998). "Folates: Supplemental forms and therapeutic applications". Altern Med Rev. 3 (3): 208–20. PMID 9630738.

[Oldref_17-7] Cravo ML, Gloria LM, Selhub J, Nadeau MR, Camilo ME, Resende MP, Cardoso JN, Leitao CN, Mira FC (1996). "Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status". The American journal of clinical nutrition. 63 (2): 220–4. PMID 8561063.

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