Nasopharyngeal carcinoma classification
Nasopharyngeal carcinoma Microchapters |
Differentiating Nasopharyngeal carcinoma from other Diseases |
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Nasopharyngeal carcinoma classification On the Web |
American Roentgen Ray Society Images of Nasopharyngeal carcinoma classification |
Risk calculators and risk factors for Nasopharyngeal carcinoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Homa Najafi, M.D.[2]Faizan Sheraz, M.D. [3]
Overview
Nasopharyngeal carcinoma may be classified according to microscopic features into 3 subtypes: keratinizing squamous cell carcinoma, nonkeratinizing carcinoma, and undifferentiated type.
Classification
Histologic classification
World Health Classification (2005) for NPC
Classification | Former name | Description | EBV | Prevalence | Prognosis |
---|---|---|---|---|---|
Keratinizing | Type 1, squamous cell
carcinoma |
graded poorly-well-differentiated | -ve | poor | |
Nonkeratinizing, differentiated | Type 2, transitional
carcinoma |
well defined cell borders & tumor nest borders | +ve | good | |
Nonkeratinizing, undifferentiated | Type 3,
lymphoepithelial carcinoma |
sheets/syncytial, vescicular nuclei, prominent nucleoli, pink cytoplasm | +ve | most common | |
Basaloid squamous cell carcinoma (BSCC) | mimics basal cell carcinoma | least common |