Testicular cancer risk factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]
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Overview
Common risk factors in the development of testicular cancer are undescended testicle, family history, personal history of testicular cancer, and Klinefelter syndrome.
Common Risk Factors
Common risk factors include:[1][2]
- Undescended testicle
- Family history of testicular cancer
- Personal history of testicular cancer
- Klinefelter syndrome
- Impaired spermatogenesis[3]
- Hypospadias
Less Common Risk Factors
Less common risk factors include:[1][4]
- Testicular microlithiasis
- HIV infection or AIDS
- Occupational exposures:[2]
- Aircraft maintenance
- Firefighting
- Early puberty
- Higher maternal age seen in seminomas type[5]
- Tall height
- Decreased fertility
- Pesticides
- Marijuana
- Prenatal exposure to estrogens
- Vasectomy
- Trauma or injury
- Tobacco
- Alcohol
References
- ↑ 1.0 1.1 Khan O, Protheroe A (October 2007). "Testis cancer". Postgrad Med J. 83 (984): 624–32. doi:10.1136/pgmj.2007.057992. PMC 2600126. PMID 17916870.
- ↑ 2.0 2.1 McGlynn KA, Trabert B (April 2012). "Adolescent and adult risk factors for testicular cancer". Nat Rev Urol. 9 (6): 339–49. doi:10.1038/nrurol.2012.61. PMC 4031676. PMID 22508459.
- ↑ Ghazarian AA, Kelly SP, Altekruse SF, Rosenberg PS, McGlynn KA (June 2017). "Future of testicular germ cell tumor incidence in the United States: Forecast through 2026". Cancer. 123 (12): 2320–2328. doi:10.1002/cncr.30597. PMC 5629636. PMID 28241106.
- ↑ "Testicular cancer: MedlinePlus Medical Encyclopedia".
- ↑ Bray F, Richiardi L, Ekbom A, Forman D, Pukkala E, Cuninkova M, Møller H (April 2006). "Do testicular seminoma and nonseminoma share the same etiology? Evidence from an age-period-cohort analysis of incidence trends in eight European countries". Cancer Epidemiol. Biomarkers Prev. 15 (4): 652–8. doi:10.1158/1055-9965.EPI-05-0565. PMID 16614105.