HIV associated nephropathy surgery
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Overview
HIV Associated Nephropathy Surgery
Kidney Transplantation
- Kidney transplantation in HIV-positive patients with end-stage renal disease (ESRD) is increasing.[1]
- A study reported a two to threefold increase in kidney rejection in patients with HIV-positive compared to HIV-negative.[2].
- In one study the incidence of rejection was 31% and 41% at 1 and 3 years, respectively.[2] In another study the acute rejection rate was 18% and 27% at 1 and 3 years, respectively.[3]
- The high rejection rate require more effective immunotherapy.[2]
- Graft survival rates were 90.4% and 73.7% at 1 and 3 years,[2] respectively in one study and 100% and 81%, respectively in another study.[3]
- While HIV-negative donor to HIV-positive recipient kidney transplantation has been carried out since 2001 60
- the concerns regarding HIV-positive to HIV-positive transplantation include HIV superinfection, resistance to cART and potential recurrence of HIVAN, in addition to inferior outcomes in general.60
- Recently, there have been reports from USA and South Africa that have shown successful kidney transplantation from HIV-positive donors to HIV-positive recipients.
References
- ↑ Palau L, Menez S, Rodriguez-Sanchez J, Novick T, Delsante M, McMahon BA; et al. (2018). "HIV-associated nephropathy: links, risks and management". HIV AIDS (Auckl). 10: 73–81. doi:10.2147/HIV.S141978. PMC 5975615. PMID 29872351.
- ↑ 2.0 2.1 2.2 2.3 Stock PG, Barin B, Murphy B, Hanto D, Diego JM, Light J; et al. (2010). "Outcomes of kidney transplantation in HIV-infected recipients". N Engl J Med. 363 (21): 2004–14. doi:10.1056/NEJMoa1001197. PMC 3028983. PMID 21083386.
- ↑ 3.0 3.1 Waheed S, Sakr A, Chheda ND, Lucas GM, Estrella M, Fine DM; et al. (2015). "Outcomes of Renal Transplantation in HIV-1 Associated Nephropathy". PLoS One. 10 (6): e0129702. doi:10.1371/journal.pone.0129702. PMC 4463848. PMID 26061701.