Analgesic nephropathy history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
History and Symptoms
| Finding | Proportion affected |
|---|---|
| Headache | 35-100% |
| Pyuria | 50-100% |
| Anemia | 60-90% |
| Hypertension | 15-70% |
| Gastrointestinal symptoms | 40-60% |
| Urinary tract infection | 30-60% |
Common findings in patients with analgesic nephropathy include headache, anemia, high blood pressure (hypertension), and white blood cells in the urine (pyuria).[1] Some individuals with analgesic nephropathy may also have protein in their urine (proteinuria).[2]
Overview
Common findings in patients with analgesic nephropathy include: headache, upper gastrointestinal disease (such as peptic ulcer), anemia, urinary tract infections, pyuria and hypertension.
History and Symptoms
History, symptoms and and clinical findings in patients with analgesic nephropathy includes:[3][2]
- Headache
- Upper gastrointestinal disease (such as peptic ulcer)
- Anemia (60%)
- Psychiatric disorder
- Urinary tract infections (15-60%)
- Sterile pyuria (95%)
- Hypertension (15-70%)
- Tubular epithelial celluria
- Microscopic hematuria (35%)
- Significant proteinuria (greater than 0.3 gr daily (40%)
- Transitional cell tumours of the urothelium (in abuse of analgesics containing phenacetin)
- Renal papillary carcinoma
- Varying degrees of renal failure (over 85%)
- Clinical gout (5%)
- Acidosis
- Passage of papillae
- Flank or abdominal pain
References
- ↑ 1.0 1.1 Murray TG, Goldberg M (1978). "Analgesic-associated nephropathy in the U.S.A.: epidemiologic, clinical and pathogenetic features". Kidney Int. 13 (1): 64–71. PMID 713270. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 Nanra RS, Stuart-Taylor J, de Leon AH, White KH (1978). "Analgesic nephropathy: etiology, clinical syndrome, and clinicopathologic correlations in Australia". Kidney Int. 13 (1): 79–92. PMID 362034. Unknown parameter
|month=ignored (help) - ↑ Nanra RS (1980). "Clinical and pathological aspects of analgesic nephropathy". Br J Clin Pharmacol. 10 Suppl 2: 359S–368S. doi:10.1111/j.1365-2125.1980.tb01824.x. PMC 1430193. PMID 7002190.