Reperfusion injury natural history
Editors-In-Chief: Anjan K. Chakrabarti, M.D. [1]; C. Michael Gibson, M.S., M.D. [2]; Dr. Shivam Singla M.D. [2] Associate Editors-In-Chief: Kashish Goel, M.D ;
Complications
Myocardial stunning: Delayed recovery, usually 2-3 days, of the viable myocardium after reperfusion is termed as "myocardial stunning". It is mainly due to the release of reactive oxygen species and intracellular calcium overload.[1]
- Myocardial infarction: Irreversible myocyte cell death secondary to reduced oxygen delivery for more than 20-30 minutes, will lead to infarction. Reperfusion helps prevent complete loss of the involved area, however oxidative stress due to this may prevent complete resolution.
- Acute heart failure: Loss of myocardial contractility and systolic dysfunction associated with ischemia/reperfusion injury may lead to development of acute heart failure. Early reperfusion in the course of STEMI prevents myocardial necrosis and may lead to complete recovery of function.
- Ventricular arrhythmias: Reperfusion of the blocked coronary artery can also precipitate arrhythmias ranging from ventricular premature beats to life-threatening ventricular fibrillation.
Prognosis
References
- ↑ Bose KS, Sarma RH, Baccanari D, Phillips A, Smith S, Sinski D, Burchall J, Jarvik LF, Milne JF, Smith RJ, Bryant RG, Smith RJ, Bryant RG, Chegwidden WR, Watts DC, Orskov ER, Fraser C, White MA (October 1975). "Delineation of the intimate details of the backbone conformation of pyridine nucleotide coenzymes in aqueous solution". Biochem. Biophys. Res. Commun. 66 (4): 1173–9. doi:10.1016/0006-291x(75)90482-9. PMID 2.