Polycythemia medical therapy
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Overview
- Phlebotomy is used to decrease blood thickness.
- Medicines that may be used include:
- Hydroxyurea: reduce the number of red blood cells made by the bone marrow. This drug may be used when the numbers of other blood cell types are also high.
- Interferon: lower blood counts.
- Anagrelide: lower platelet counts.
- Ruxolitinib (Jakafi): reduce the number of red blood cells and reduce an enlarged spleen. This drug is prescribed when hydroxyurea and other treatments have failed.
- Aspirin: reduce the risk of blood clots.
- Ultraviolet-B light therapy: reduce the itchiness.
Overview
- Phlebotomy is used to decrease blood thickness.
- Medicines that may be used include:[1]
- Hydroxyurea: it used to reduce red blood cells counts and other blood cells if high. It also used to prevent thrombosis in patients >60 years of age with chronic PV.
- Interferon: reduce blood cell counts.PegIFN can be used to reduce established splenomegaly but not usually to normal size.
- Anagrelide: used to treat thrombocytosis.
- Ruxolitinib (JAK1/2 inhibitor): proved to be effective in PPMF and chronic-phase PV; provided durable symptom relief, blood count control, and reduction in splenomegaly; and was superior to hydroxyurea.
- Aspirin: used to prevent thrombosis.
- Ultraviolet-B light therapy: reduce the itchiness.
References
- ↑ Spivak JL (2019). "How I treat polycythemia vera". Blood. 134 (4): 341–352. doi:10.1182/blood.2018834044. PMID 31151982.