Polycythemia medical therapy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]

Overview

• Phlebotomy is used to decrease blood thickness.
• Medicines that may be used include:
  • Hydroxyurea: it used to reduce red blood cells counts and other blood cells if high. It also used to prevent thrombosis in patients >60 years of age with chronic PV.
  • Interferon: reduce blood cell counts.PegIFN can be used to reduce established splenomegaly but not usually to normal size.
  • Anagrelide: used to treat thrombocytosis.
  • Ruxolitinib (JAK1/2 inhibitor): proved to be effective in PPMF and chronic-phase PV; provided durable symptom relief, blood count control, and reduction in splenomegaly; and was superior to hydroxyurea.
  • Aspirin: used to prevent thrombosis.
• Ultraviolet-B light therapy: reduce the itchiness.

Overview

• Phlebotomy is used to decrease blood thickness.
• Medicines that may be used include:
  • Hydroxyurea: it used to reduce red blood cells counts and other blood cells if high. It also used to prevent thrombosis in patients >60 years of age with chronic PV.
  • Interferon: reduce blood cell counts.PegIFN can be used to reduce established splenomegaly but not usually to normal size.
  • Anagrelide: used to treat thrombocytosis.
  • Ruxolitinib (JAK1/2 inhibitor): proved to be effective in PPMF and chronic-phase PV; provided durable symptom relief, blood count control, and reduction in splenomegaly; and was superior to hydroxyurea.
  • Aspirin: used to prevent thrombosis.
• Ultraviolet-B light therapy: reduce the itchiness.