Polycythemia diagnostic study of choice

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S [2]

Overview

The polycythemia vera study group is considered to be the gold standard test for the diagnosis of polycythemia vera; however, it does not take into account bone marrow histopathology. ^[1]

Clinical features that significantly differentiate primary vs secondary polycythemia are: splenomegaly, thrombocyte count, LDH, LAP, and erythropoietin. ^[2]

↑ Thiele J, Kvasnicka HM (January 2005). "Diagnostic impact of bone marrow histopathology in polycythemia vera (PV)". Histol Histopathol. 20 (1): 317–28. doi:10.14670/HH-20.317. PMID 15578448.
↑ Thiele J, Kvasnicka HM, Zankovich R, Diehl V (April 2001). "The value of bone marrow histology in differentiating between early stage Polycythemia vera and secondary (reactive) Polycythemias". Haematologica. 86 (4): 368–74. PMID 11325641.