Pneumoconiosis future or investigational therapies
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Dushka Riaz, MD
Overview
Future or Investigational Therapies
Future therapies are being experimented on including inhibiting cytokines and the use of antioxidants. Investigational therapy also includes administration of bone marrow-derived mononuclear cells. [1] [2] [3] In the case of berylliosis, the use of 5-aminosalicylic acid (ASA) is being considered as it improved the beryllium lymphocyte proliferation test (BeLPT) test by 20% after use for six weeks. [4]
References
- ↑ Rimal B, Greenberg AK, Rom WN (2005). "Basic pathogenetic mechanisms in silicosis: current understanding". Curr Opin Pulm Med. 11 (2): 169–73. doi:10.1097/01.mcp.0000152998.11335.24. PMID 15699791.
- ↑ Maron-Gutierrez T, Castiglione RC, Xisto DG, Oliveira MG, Cruz FF, Peçanha R; et al. (2011). "Bone marrow-derived mononuclear cell therapy attenuates silica-induced lung fibrosis". Eur Respir J. 37 (5): 1217–25. doi:10.1183/09031936.00205009. PMID 20693250.
- ↑ Cavalli G, Fallanca F, Dinarello CA, Dagna L (2015). "Treating pulmonary silicosis by blocking interleukin 1". Am J Respir Crit Care Med. 191 (5): 596–8. doi:10.1164/rccm.201412-2150LE. PMID 25723826.
- ↑ Day BJ, Huang J, Barkes BQ, Gillespie M, Li L, Maier LA (2018). "5-Aminosalicylic Acid Modulates the Immune Response in Chronic Beryllium Disease Subjects". Lung. 196 (1): 103–114. doi:10.1007/s00408-017-0062-x. PMID 29080069.