Caplans syndrome pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
The exact pathogenesis of [disease name] is not fully understood.
OR
It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].
OR
[Pathogen name] is usually transmitted via the [transmission route] route to the human host.
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Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.
OR
[Disease or malignancy name] arises from [cell name]s, which are [cell type] cells that are normally involved in [function of cells].
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The progression to [disease name] usually involves the [molecular pathway].
OR
The pathophysiology of [disease/malignancy] depends on the histological subtype.
Pathophysiology
Pathogenesis
- It is understood that syndrome is the result of alteration of immune response in the patients with Rheumatoid arthritis.[1]
- There is an increased immune response to foreign materials in the lungs.Silica initiates hyperactive immune responses in the coal miners with Rheumatoid arthritis
- Macrophages engulf silica particles, causing inflammation which eventually activate the firbroblasts.
- Due to having apoptotic capacity, engulfed silica destroy the macrophages and again get taken up by another macrophage. This continued process activates chronic immune response and fibrosis.
Genetics
No genetic association is found in Caplan Syndrome.
Associated Conditions
Conditions associated with [disease name] include:
Gross Pathology
Some people who have been exposed to the dust have severe lung scarring that makes it difficult for their lungs to carry oxygen to the bloodstream (called progressive massive fibrosis). People with rheumatoid arthritis do not seem more likely to have this complication of scarring.
Persons with rheumatoid arthritis are more likely to develop larger areas of inflammation and scarring in response to coal dust.
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].