Cervicitis diagnostic study of choice
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Zehra Malik, M.B.B.S[2]
Overview
Diagnostic Study of Choice
Study of choice
There is no single diagnostic study of choice for the diagnosis of cervicitis.
- There are two major diagnostic signs that characterize cervicitis[1][2]
- Abnormal vaginal bleeding:
- Purulent or mucopurulent endocervical exudate visible in the endocervical canal or on an endocervical swab specimen (commonly referred to as mucopurulent cervicitis)
- Sustained endocervical bleeding is easily induced by gentle passage of a cotton swab through the cervical os.
- Cervicitis is usually asymptomatic, symptoms observed include:[3][4]
- Abnormal vaginal discharge
- Intermenstrual vaginal bleeding (e.g., especially after sexual intercourse)
- Increased number of WBCs on endocervical Gram stain in the diagnosis of cervicitis has not been standardized; it is not sensitive, has a low positive predictive value for C. trachomatis and N. gonorrhea infections, and is not available in most clinical settings.
- Leukorrhea, defined as >10 WBCs/HPF on microscopic examination of vaginal fluid, might be a sensitive indicator of cervical inflammation with a high negative predictive value (i.e., cervicitis is unlikely in the absence of leukorrhea).
- Presence of gram-negative intracellular diplococci on Gram stain of endocervical exudate might be specific for diagnosing gonococcal cervical infection when evaluated by an experienced laboratorian, it is not a sensitive indicator of infection
References
- ↑ Marrazzo JM, Wiesenfeld HC, Murray PJ, Busse B, Meyn L, Krohn M; et al. (2006). "Risk factors for cervicitis among women with bacterial vaginosis". J Infect Dis. 193 (5): 617–24. doi:10.1086/500149. PMID 16453256.
- ↑ Dunlop EM, Garner A, Darougar S, Treharne JD, Woodland RM (1989) Colposcopy, biopsy, and cytology results in women with chlamydial cervicitis. Genitourin Med 65 (1):22-31. PMID: 2921049
- ↑ Holló P, Jókai H, Herszényi K, Kárpáti S (2015). "[Genitourethral infections caused by D-K serotypes of Chlamydia trachomatis]". Orv Hetil. 156 (1): 19–23. doi:10.1556/OH.2015.30078. PMID 25544050.
- ↑ Barlow D, Phillips I (1978). "Gonorrhoea in women. Diagnostic, clinical, and laboratory aspects". Lancet. 1 (8067): 761–4. PMID 76760.