Beta-thalassemia history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]

History and Symptoms

Major variant patients present in early infancy with:

• Severe anemia
• Failure to thrive
• Pallor
• Jaundice
• Fatigue
• Growth retardation

After treatment initiation, they would have symptoms of iron overload due to multiple transfusions which may cause:

• Fatigue and weakness
• Arthritis
• Abdominal pain
• Bronzed or grayish skin
• Loss of libido
• Hormonal imbalances
• Cognitive problems Intermedia variant patients might experience moderate anemia, splenomegaly, bone changes, and intermittent need for blood transfusions at different ages

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