Myasthenia gravis classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]

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Overview

Classification

The most widely accepted classification of myasthenia gravis is the Myasthenia Gravis Foundation of America Clinical Classification:[1]

  • Class I: Any eye muscle weakness, possible ptosis, no other evidence of muscle weakness elsewhere
  • Class II: Eye muscle weakness of any severity, mild weakness of other muscles
    • Class IIa: Predominantly limb or axial muscles
    • Class IIb: Predominantly bulbar and/or respiratory muscles
  • Class III: Eye muscle weakness of any severity Moderate weakness of other muscles
    • Class IIIa: Predominantly limb or axial muscles
    • Class IIIb: Predominantly bulbar and/or respiratory muscles
  • Class IV: Eye muscle weakness of any severity, severe weakness of other muscles
    • Class IVa: Predominantly limb or axial muscles
    • Class IVb: Predominantly bulbar and/or respiratory muscles (Can also include feeding tube without intubation)
  • Class V: Intubation needed to maintain airway

References

  1. Jaretzki A, Barohn RJ, Ernstoff RM; et al. (2000). "Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America". Neurology. 55 (1): 16–23. PMID 10891897.