Eosinophilia

Eosinophilia
DiseasesDB	4328

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Lakshmi Gopalakrishnan, M.B.B.S. [2]

Overview

• Eosinphilia refers to a group of idiopathic, neoplastic, infectious and allergic illnesses
• Eosinphilia is associated with abnormally high number of eosinphil granulocytes in the serum and/or tissue
• Reference range: 0-450 ul

Differential Diagnosis of Causes of Eosinophilia

By Organ System

Cardiovascular	Endomyocardial fibrosis, Cholesterol embolism, Loeffler endocarditis , Eosinophilic myocarditis
Chemical / poisoning	No underlying causes
Dermatologic	Erythema multiforme, Atopic dermatitis, Dermatitis herpetiformis, Eosinophilic fasciitis, Eosinophilic pustular folliculitis, Pemphigus vulgaris, Psoriasis, Systemic lupus erythematosus, Sarcoptes scabiei, Eczema , Exfoliative dermatitis , Urticaria , Eosinophilic panniculitis , Shulman’s syndrome , Stevens - Johnson syndrome , Duhring disease , Histiositosis with cutaneous involvement
Drug Side Effect	Sulphonamides, Allopurinol, Amitriptyline, Capreomycin, Caspofungin, Chlorpropamide, Clomipramine, Daptomycin, Desipramine, Dothiepin, Doxycycline, Enfuvirtide, Etravirine, Gold salts, Granulocyte-macrophage colony stimulating factor, Hydralazine, Imipramine, Interleukin 2, Micafungin, Minocycline, Nalidixic acid, Nitrofurantoin, Nortriptyline, Olanzapine, Oxytetracycline, Pentostatin, Procarbazine, Tobacco smoking, Tryptophan, Vancomycin, Aldesleukin , Amikacin Sulfate , Capastat Sulfate , Capreomycin Sulfate , Cefotaxime Sodium , Cefoxitin Sodium , Ceftazidime , Cefuroxime , LyphocinMaolate
Ear Nose Throat	No underlying causes
Endocrine	Adrenal cortex insufficiency, Addisons disease , Adrenocortical insufficiency
Environmental	An allergic reaction to an environmental antigen
Gastroenterologic	Inflammatory Bowel Disease , Cirrhosis of liver , Chronic active hepatitis , Eosinophilic Gastroenteritis , Peritoneal dialysis
Genetic	Autoimmune lymphoproliferative syndrome type 1, Autoimmune lymphoproliferative syndrome type 2, Familial eosinophilia, Kostmann disease, Omenn syndrome, Wiskott-Aldrich syndrome, TAR syndrome, kostmann syndrome, Chromosome 21 partial deletion
Hematologic	Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma, Thrombocytopenia with absent radii , Familial reticuloendotheliosis with eosinophilia
Iatrogenic	Radiotherapy
Infectious Disease	Acanthocheilonemiasis, Alveolar hydatid disease, Ancylostoma caninum, Ancylostoma duodenale, Angiostrongyliasis, Anisakiasis, Ascariasis, Capillaria, Clonorchiasis, Coccidioidomycosis, Dicrocoelium dendriticum fluke, Dracunculiasis, Echinococcus granulosus, Fasciola hepatica, Gnathostomiasis, Heterophyiasis, Lepromatous leprosy, Loa loa filariasis, Lymphatic filariasis, Mansonelliasis, Metagonimiasis, Mycobacterium tuberculosis, Onchocerciasis, Opisthorchiasis, Paragonimiasis, Schistosoma haematobium, Schistosoma mansoni, Strongyloidiasis, Toxocariasis, Trichinella spiralis, Pneumocystis jirovecii infection , Visceral larva migrans , Brucellosis , Cat-scratch fever , Chlamydial pneumonia of infancy , Infectious lymphocytosis , Infectious mononucleosis , Scarlet fever, Amebiasis , Malaria
Musculoskeletal / Ortho	Polyarteritis nodosa, Polymyositis, Rheumatoid disease, Dressler's syndrome , Eosinophilic fasciitis , Idiopathic eosinophilic synovitis , Progressive systemic sclerosis (scleroderma) , SLE , Sjögren's syndrome , Sarcoidosis , Eosinophilia – Myalgia syndrome , Dermatomyositis
Neurologic	No underlying causes
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia, Chronic myeloid leukaemia, Hodgkin lymphoma, Immunoblastic lymphadenopathy , Sarcomas and carcinomas of ovary, Carcinoma of pancreas , Carcinoma of lung , Carcinoma of colon, Carcinoma of cervix , Acute eosinophilic leukemia , Chronic eosinophilic leukemia , Brain tumors
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Simple pulmonary eosinophilia, Visceral larva migrans, Allergic bronchopulmonary aspergillosis, Extrinsic allergic alveolitis, Tropical pulmonary eosinophilia, Churg-Strauss syndrome, Bronchial asthma, Allergic Rhinitis, Chronic eosinophilic pneumonia , Occupational lung diseases , Idiopathic eosinophilic chronic pneumopathy , Magrassi- Leonardi syndrome
Renal / Electrolyte	Interstitial nephritis, Eosinophilic cystitis , Hemodialysis , CRF not on renal replacement therapy , Diffuse proliferative glomerular nephritis , Thrombotic thrombocytopenic purpura , Renal cell carcinoma
Rheum / Immune / Allergy	Eosinophilia-myalgia syndrome,Hyper-IgE syndrome , IgA deficiency , Wiskott-Aldrich syndrome ,Graft versus host immunologic reactions ,Milk protein allergy , Omenn syndrome , Severe congenital Neutropenia
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Miscellaneous	Angiolymphoid hyperplasia with eosinophilia, Eosinophilic cellulitis, Hypereosinophilic syndrome, Kimura disease, Familial eosinophilia , Episodic angioedema with eosinophilia , Aggressive systemic mastocytosis

In alphabetical order

• Acanthocheilonemiasis

• Acute lymphoblastic leukemia

• Acute eosinophilic leukemia

• Chronic eosinophilic leukemia

• Addisons disease

• Adrenocortical insufficiency

• Aggressive systemic mastocytosis

• Aldesleukin

• Allergic bronchopulmonary aspergillosis

• Allergic Rhinitis

• Allopurinol

• Alveolar hydatid disease

• Amebiasis

• Amikacin Sulfate

• Amitriptyline

• Ancylostoma caninum

• Ancylostoma duodenale

• Angiolymphoid hyperplasia with eosinophilia

• Angiostrongyliasis

• Anisakiasis

• Ascariasis

• Atopic dermatitis

• Autoimmune lymphoproliferative syndrome type 1

• Autoimmune lymphoproliferative syndrome type 2

• Brain Tumors

• Bronchial asthma

• Brucellosis

• Capastat Sulfate

• Capillaria

• Capreomycin

• Caspofungin

• Cat-scratch fever

• Cefotaxime Sodium

• Cefoxitin Sodium

• Ceftazidime

• Cefuroxime

• Chlamydial pneumonia of infancy

• Chlorpropamide

• Cholesterol embolism

• Chromosome 21 partial deletion

• Chronic active hepatitis

• Chronic eosinophilic pneumonia

• Chronic myeloid leukaemia

• Churg-Strauss syndrome

• Cirrhosis

• Cirrhosis of liver

• Clomipramine

• Clonorchiasis

• Coccidioidomycosis

• CRF not on renal replacement therapy

• Daptomycin

• Dermatitis herpetiformis

• Dermatomyositis

• Desipramine

• Dicrocoelium dendriticum fluke

• Diffuse proliferative glomerular nephritis

• Dothiepin

• Doxycycline

• Dracunculiasis

• Dressler's syndrome

• Duhring's disease

• Echinococcus granulosus

• Eczema

• Endomyocardial fibrosis

• Enfuvirtide

• Eosinophilia – myalgia syndrome

• Eosinophilic cellulitis

• Eosinophilic cystitis

• Eosinophilic fasciitis

• Eosinophilic gastroenteritis

• Eosinophilic myocarditis

• Eosinophilic panniculitis

• Eosinophilic pustular folliculitis

• Episodic angioedema with eosinophilia

• Erythema multiforme

• Etravirine

• Exfoliative dermatitis

• Extrinsic allergic alveolitis

• Familial eosinophilia

• Familial eosinophilia

• Familial reticuloendotheliosis with eosinophilia

• Fasciola hepatica

• Gnathostomiasis

• Gold salts

• Graft versus host immunologic reactions

• Granulocyte-macrophage colony stimulating factor

• Hemodialysis

• Heterophyiasis

• Histiositosis with Cutaneous involvement

• Hodgkin lymphoma

• Hydralazine

• Hypereosinophilic syndrome

• Hyper-IgE syndrome

• Idiopathic eosinophilic chronic pneumopathy

• Idiopathic eosinophilic synovitis

• IgA deficiency

• Imipramine

• Immunoblastic lymphadenopathy

• Infectious lymphocytosis

• Infectious mononucleosis

• Inflammatory Bowel Disease

• Interleukin 2

• Interstitial nephritis

• Kimura disease

• Kostmann syndrome

• Lepromatous leprosy

• Loa loa filariasis

• Loeffler endocarditis

• L-Tryptophan use

• Lymphatic filariasis

• Lyphocin maolate

• Magrassi- Leonardi syndrome

• Malaria

• Mansonelliasis

• Metagonimiasis

• Micafungin

• Milk protein allergy

• Minocycline

• Mycobacterium tuberculosis

• Nalidixic acid

• Nitrofurantoin

• Nortriptyline

• Occupational lung diseases

• Olanzapine

• Omenn syndrome

• Onchocerciasis

• Opisthorchiasis

• Oxytetracycline

• Paragonimiasis

• Pemphigus vulgaris

• Pentostatin

• Peritoneal dialysis

• Pneumocystis jirovecii infection

• Polyarteritis nodosa

• Polymyositis

• Procarbazine

• Progressive systemic sclerosis (scleroderma)

• Psoriasis

• RA

• Radiation therapy

• Radiotherapy

• Renal cell carcinoma

• Sarcoidosis

• Sarcomas and carcinomas of Ovary/ Cervix Pancreas Lung, colon

• Sarcoptes scabiei

• Scarlet fever

• Schistosoma haematobium

• Schistosoma mansoni

• Severe congenital Neutropenia

• Shulman’s syndrome

• Simple pulmonary eosinophilia

• Sjögren's syndrome

• SLE

• Stevens - Johnson syndrome

• Strongyloidiasis

• Sulphonamides

• Systemic lupus erythematosus

• TAR syndrome

• Thrombocytopenia with absent radii

• Thrombotic thrombocytopenic purpura

• Tobacco smoking

• Toxocariasis

• Trichinella spiralis

• Tropical pulmonary eosinophilia

• Tryptophan

• Urticaria

• Vancomycin Hydrochloride

• Vancomycin

• Visceral larva migrans

• Wiskott-Aldrich syndrome

Related Chapters

• Leukocytosis
• Granulocytosis
• Neutrophilia
• Monocytosis
• Lymphocytosis

References

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