Mantle cell lymphoma other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Other diagnostic studies for the diagnosis of mantle cell lymphoma include genetic testing, FISH, PCR, bone marrow aspiration, lumbar puncture, colnoscopy, upper endoscopy, cytogenetic analysis, flow chemistry, immunohistochemistry, laparoscopy, and laparatomy.

Other Diagnostic Studies

Genetic Testing

• Heavy and light chain genes rearranged, t(11;14)(q13;q32) in virtually all cases
• Overexpression CYCLIN D mRNA
• Mutation or deletions of ATM gene

FISH

Diagnosis generally requires stained slides of a surgically removed part of a lymph node. Other methods are also commonly used, including cytogenetics and fluorescence in situ hybridization (FISH).

PCR

Polymerase chain reaction (PCR) and CER3 clonotypic primers are additional methods, but are less often used.

Immunophenotype

BCL6-, CD5+, CD10-, CD23- (or weakly positive), CD43+, FMC7+

Bone Marrow Aspiration

Mantle cell lymphoma is a systemic disease with frequent involvement of the bone marrow and gastrointestinal tract (generally showingpolyposis in the lining). There is also a not-uncommon leukemic phase, marked by presence in the blood. For this reason, both the peripheral blood and bone marrow are evaluated for the presence of malignant cells.

Lumbar Puncture

In some patients with the blastic variant, lumbar puncture is done to evaluate the spinal fluid for involvement.

Colonoscopy

Since mantle cell lymphoma may present a lymphomatous polyposis coli and colon involvement is common, colonoscopy is now considered a routine part of the evaluation.

Upper Endoscopy

Upper endoscopy may be helpful in selected cases.