Sideroblastic anemia causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

The common feature of these causes is a failure to completely form heme - whose biosynthesis takes place partly in the mitochondrion. This leads to deposits of iron in the mitochondria that form a ring around the nucleus of the developing red blood cell. Sometimes the disorder represents a stage in evolution of a generalized bone marrow disorder that may ultimately terminate in acute leukemia.

• Toxins: lead or zinc poisoning
• Drug-induced: ethanol, isoniazid, chloramphenicol, cycloserine
• Nutritional: pyridoxine or copper deficiency
• Genetic: ALA synthase deficiency (X-linked)