Aortic stenosis risk factors

	Aortic Stenosis Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editors-In-Chief: Mohammed A. Sbeih, M.D. [2]; Assistant Editor-In-Chief: Kristin Feeney, B.S. [3]

Overview

The most common risk factor for the development of aortic stenosis is the presence of a congenital bicuspid aortic valve.

Age-related progressive calcification of the normal tricuspid aortic valve (>50% of cases).
Congenital bicuspid aortic valve that may subsequently become calcified later in life (30-40% of cases). Normal aortic valve have three leafs (tricuspid), but some valves have two leafs (bicuspid). Typically, aortic stenosis due to calcification of a bicuspid valve appears earlier, in the 40s and 50s, whereas that due to calcification of a normal valve appears later, in the 70s and 80s.
Acute rheumatic fever (less than 10% of cases).

Other risk factors that may speed up the progression of aortic stenosis include: