Acute liver failure future or investigational therapies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]

Overview

Liver support systems help in supporting the patients until the liver recovers or can be used as a bridging aid for transplantation.

Liver Support Systems

Liver Support Systems are the support devices helping in providing some time to help failing liver to recover. These can also be used as a bridge to transplantation. There are two kinds of devices sorbent based artificial system and cell based bio-artificial system. There is no good evidence showing low mortality with their use in acute liver failure. They are not recommended outside of clinical trials as of now.

Other Strategies

Other strategies include exchange transfusion, charcoal hemoperfusion, extracorporeal liver perfusions, and intra-portal hepatocyte infusions. All these are still under trials and no evidence of good prognosis is demonstrated.